Use of Peptide Therapy in Creation of Eye Serums

Take out a little bit of your high school chemistry for this lesson; it is going to help you identify exactly what that eye serum you want to use contains and whether the ingredients are effective. There are many products, all promising the moon in terms of eliminating crows' feet, wrinkles and fine lines, especially around the eyes.

Most of the manufacturing companies buy peptides in Canada to use in the serums because of the known benefits of peptides in fighting age. These peptides are usually made only for research or manufacturing purposes by dynamic biotechnology companies in Canada. The chemists in these industries will program the peptide to accomplish a certain task in the body. In eye serums for instance, this task is the stimulation of collagen production.
How it works
Serum peptide formulations are programmed to convey useful bioactive ingredients to the sensitive regions of the eye. These ingredients will the trigger more production of collagen. Collagen works with elastin (constitutive ratio is 14:1) in the skin to give the quality of elasticity and plumpness.
By the time women hit forty, 15% of their normal collagen production will be lost, dropping further to 45% by age 60. Creams with peptides Canada applied topically to the major sites of collagen loss like around the eyes will counteract this effect and stimulate collagen production. The result is not only to boost collagen, but also wrinkles and fine line already existing will smooth out.
Pentapeptides and neuropeptides
Neuropeptides are small polypeptide chains that influence the nervous system to react a certain way e.g. production of certain chemical signals. In anti-aging serums and topical creams, neuropeptides may be used to activate cell receptor sites in order to gain maximal benefits from the serum/cream. These peptides are usually delivered within a special base to allow fast and complete absorption into the skin.
Pentapeptides are also common agents used in anti-aging formulations. Like the name suggests, these are peptides made from five amino acids joined with peptide bonds. They signal for collagen production in the skin, but are not as sophisticated in the operative mechanism as the latter class of peptides. They are, however, very useful in wound healing due to their role in the production of collagen, a mechanism the cosmetic industry capitalizes on.
There are two main pentapeptides for cosmetic companies purchase from Canada peptides companies: acetyl hexapeptide and palmitoyl pentapeptide. Of course, there are also many more options. There also is the option of direct injection to sites, which is still under research and a cause for much controversy.

How You Can Arouse a Woman Instantly Using Alpha Male Body Language

A man can instantly arouse a woman using alpha male body language. You need to know what type of body language women find desirable which you must display to be able to use alpha male body language to arouse a woman. You will learn from this article how you can instantly arouse a woman and make a woman feel strong romantic attraction to you using alpha male body language.

If you want to instantly arouse a woman you will have to learn how to glare at her or other ladies around passionately. While it is repulsive to many women when you stare continuously at their chest and hips, you need to briefly glare occasionally at them intentionally so that a woman will know that you find her desirable romantically and you are not just another male friend around. Some women only find a man romantically attractive when they know that he find them passionately attractive and then the women will start thinking in that direction subconsciously. One good way players do this is by looking at other women that are passing that have notable chest or those that have beautiful hips while they are talking to a woman whom they are trying to arouse and this will make the lady they are talking to start feeling that he is a romantic guy who want more than friendship with girls. You can create emotional confusion in a woman and instantly arousing a woman when you are talking with her about non romantic topic and you are taking occasional glare at her passionate zones.

You need to have self confidence to be able to arouse a woman instantly. Many women fantasize about guys who are their knight, who passionate overpower them and take them to the dream adventous land. When a man have self confidence and is relating to women, such thoughts start coming back to their mind. Most times a beautiful woman will try to display initial resistance to the flirting effort of a man but will eventually follow any man anywhere when she discover that he is self confident and he is persisting in his flirting effort. Most beautiful women like testing a man to see if he has self confidence by dictating to him or trying to control him to see how he will react. One thing that can instantly arouse a woman is when she is in the presence of a man and she feel he is an alpha male. Women will immediately take you to be an alpha male if you show to women that you have self confidence. When a man show consideration to a woman but tell her directly how and when they should have a date, the woman will start feeling strong attraction towards the man and this will lead to the man been able to instantly arouse the woman.

For you to instantly arouse women you need to be a game guy that is you do not take women too seriously. Alpha males know that women are aroused by men who are relax and not trying hard to impress people around especially beautiful girls. When you get to a public place look for big sitting chairs and rest your body fully on it and spread your hands and legs. Women coming will immediately feel arouse by your presence. Also if a girl is the center of attention of most guys in a social setting, try to focus your attention on other girls and make them to cluster around you. If you are able to keep the girls around you laughing and talking, the beautiful woman watching from a distance will immediately start feeling instant attraction to you. If you are able to keep more than one group of girls laughing and suddenly leave them behind for the next, most girls will want to get close to you. What you have just done is making the beautiful women understand that that you have the ability to make women happy but you will only do that to only few special girls who deserve your attention. Since you have played the game guy, you will notice that you will be able to arouse most women instantly.

From this article you have seen how you can arouse a woman instantly from the first time that you meet her. You will be able to arouse a woman if you are able to make her feel romantically attracted to you from the first moment.

Nephron Sparing Surgery in Renal Tumors: A Case Report

A 69 yrs old male presented to our OPD with h/o left sided varicocele. A known case of Diabetes, hypertension and bilateral medical renal disease, he underwent MRI abdomen which revealed a large lower pole lesion in left kidney with no renal vein or IVC thrombus. DTPA Scan revealed a 61% function in the affected kidney. Due to his bilateral medical renal disease and poorly functioning contra lateral kidney, he was planned for Nephron Sparing Surgery / partial nephrectomy (L) and DJ Stenting under cold ischaemia. Post op patient initially showed a rise in creatinine levels which gradually settled down to pre operative levels.

Before we go into the discussion of partial nephrectomy or nephron sparing surgery (NSS) in RCC, I would like to emphasize on the presenting complaint. Varicocele in the left side is one of the presentation of Left sided kidney mass, which occurs due to the drainage of the gonadal vein into the renal vein on the left side and generally indicates tumor thrombus in the venous system renal/ IVC, however in this case it was because of compression of left gonadal vein by the renal mass.

Renal tumors comprise approximately 3.8% of all new cancers with median age at diagnosis of 64 yrs. It is the third most common urological malignancy. The rate of RCC has increased by 1.6% per year for last 10 yrs, the reason of which is unknown. Majority of them are renal cell carcinomas and 80% of them are clear cell variety.
Smoking and obesity are high risk factors of RCC. Some genetic diseases are also associated with RCC, like Von Hippel Lindau (VHL) disease.
At presentation 25% are locally advanced. More often patient presents with metastatic disease (20%). Only a few patients present with Virchows Triad - the €too late triad' ( of hematuria, abdominal pain and flank mass). A CT Scan or MRI of the whole abdomen including pelvis clinches the diagnosis. A NEEDLE BIOPSY IS NOT NECESSARY BEFORE SURGERY IF THERE ARE CLEAR FINDINGS IN IMAGING. It is only required when non surgical intervention is planned or if the patient is planned to be kept under surveillance only.

Surgery is the only definitive curative treatment for renal cancer, either in the form of NSS/ Radical Nephrectomy. Any of the open, laparoscopic or robotic techniques may be employed for either of the two procedures; with each having its own advantages and disadvantages.Types of Partial Nephrectomy are Polar segmental resection, Wedge resection, Major transverse resection and Bench resection & auto transplant.

Indications for Open partial nephrectomy BOX 1
€ Solitary kidney
€ Large tumour
€ Central tumour
€ Multiple tumours
€ Requirement for cooling
€ Ischaemia > 30 min

Indications for Minimally Invasive techniques BOX2
€ Small < 3cm
€ Non central lesion

Originally partial nephrectomy (NSS) was indicated only in the clinical settings in which radical nephrectomy would make patient functionally anephric or patient will require dialysis, like RCC in solitary kidney, but now it is becoming more common. The absolute indications are Solitary kidney, bilateral renal masses and Renal Impairment. There are also relative indications like small unilateral tumors and hereditary RCC. Partial nephrectomy has same oncological outcome till the stage 1B tumors, i.e, till a size of 7 cm tumor. Node dissection has no survival advantage and is a staging procedure only. At least 20% RCC cases are suitable for NSS. Cold ischemia is preferred in those cases where we anticipate the operative time following clamping of the renal artery to be prolonged. If we clamp renal artery for more than 60 minutes in warm ischemia, then the recovery is incomplete and 60-70% of the renal function is lost, while the same for 20-30 minutes leads to complete renal recovery, and in cold ischemia we can save the function of the kidney even till 60 minutes.

Studies with limited follow up reveal that the oncological outcome for laparoscopic Vs open partial nephrectomy appears to be similar. However, it was shown that operative and post operative complications are fewer in open surgery. Radical nephrectomy should not be employed when partial nephrectomy or NSS can be achieved (1) Pts with partial nephrectomy show better survival than radical nephrectomy. (2,3)

Surgical resection remains an effective therapy for clinically localized RCC, with options including radical nephrectomy (open, laparoscopic, robotic) or nephron sparing surgery. Each of these modalities is associated with its own benefits and risks, the balance of which should optimise long term renal function and expected cancer free survival.

References:
1. Urology 2010;76:631-637.
2. JAMA 2012 apr 18;307(15):1629-35.
3. J Urology 2008; 179:468-471; discussion472-483
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Immuno-Oncology: Novel, Effective and Efficient Therapy for Cancer Treatment

There is a drastic change in the therapies used to curb cancer but still immunotherapy is the most effective and prominent one. Researches and advancements are still made to make the immune system of a person stronger.
Growth has dependably been an enormous and repulsive illness for the individuals who experience the ill effects of it, as well as for the masses. Till the most recent two centuries, individuals were reliant just on routine systems for treatment. Be that as it may then in 1891, William Coley spearheaded in the field of immunotherapy.
Despite of the fact that his discoveries were not up to the imprint, yet he gave scientists a right to gain entrance to the new field for the treatment of growth. The ebb and flow situation is that scientists are investigating a few different techniques to focus on the tumor cells at sub-atomic level.
Thus, what precisely is this immunotherapy? It is sort of like self-preservation. You are using your body's own invulnerable framework against this frightful ailment. Consider your body as nation and insusceptible framework as its military. The infections, microbes' are the remote country's armed force that is attempting to attack your country. Such irresistible specialists have an exceptional thing called antigens that help the powers to remember them and keep them under control. Our country's energy has a database of their inhabitants. Yet, in some cases they are not able to separate between their own particular inhabitants and outside powers or the outer armed force is strong to the point that our armed force is not able to stop them. This results in the advancement of malignancy.
A different methodology used in this field incorporates: utilization of monoclonal antibodies, immunization treatments and summed up immunotherapies. Monoclonal antibody utilizes artificially created proteins of insusceptible framework. Immunizations implied for tumor are produced to start a solid insusceptible reaction against remote operators as opposed to murdering them all alone. Generalized immunotherapies like cytokines and interferon's provide assistance to help the immune system of an influenced individual.
This help can possibly offer you a superior personal satisfaction with minimum conceivable reactions. The survival rate and viability is apparent. You will have the capacity to see the impacts in a short compass of time. A percentage of the medications identified with this treatment have been sanction by FDA while others are as yet experiencing clinical trials.
Immune oncology is most likely going to demonstrate an extraordinary headway in the field of treatment regimens for growth. Despite the fact that, the examination is still in its beginning stages and a great deal needs to be carried out, yet various operators like cytokines and monoclonal antibodies have effectively made their imprint as a growth treatment help. Future prospects are high to battle growth.

Communication in a Relationship

Communication is a vital part of our lives: a typical day involves many interactions between ourselves, our work colleagues and clients, our children, our friends, our ex's, future relationships, etc. This interaction takes place where we live, work, relax, socialize and wherever we perform routine tasks.

Communication skills are critical for building healthy relationships, especially when one realizes that one of the most common causes of relational breakdown is a lack of communication. Just as communication can be the most important part of a relationship; arguments can be the most destructive aspect - the closer we are to someone, the more easily we can bruise or be bruised. There is very little truth in the saying: "Sticks and stones may break my bones, but words can never harm me." It's not what we say, but rather how we say it, that most often hurts another person.

Do you identify with any of these statements?

"He never listens to me when I talk!"

"She talks and talks, but never actually says anything!"

"It's like talking to a brick wall"

"I can't get through to you"

"We can't talk about anything important without getting into a fight"

"She's too emotional - she's either crying or shouting or complaining. It's easier to avoid her"

"He always gets defensive when I try to talk about issues"

Communication is a complex process; of which speaking only makes up for 10-20%. The other 80-90% is made up by facial expressions, body language, tone of voice, etc.

Communication is the art/ science of transferring a thought/ idea/ information from the mind of one complex human being to the mind of one or more complex human being(s). For communication to be effective, it must be a two-way process.

Dynamics of Interpersonal Communication

1. Facts: are both people communicating about the same set of facts? Try to separate the facts from thoughts or feelings.

2. Interpretations, Thoughts or Perceptions: Each person interprets a fact differently based on their belief system, personality, values and experience.

3. Feelings: how we are feeling, our current mood and frame of mind, etc can sub-consciously affect decisions and thoughts.

4. Intentions, Needs or Wants: hidden agendas; are we looking for comfort, clarification, information or simply a chance to interact? We judge ourselves on our intentions.

5. Actions: choice of words (is the intent to create harm?) + tone of voice + non-verbal speech = body language, posture, eye contact, facial expressions, etc.

"The medium is the message" => the way the message is delivered is the message itself.

6. Self: The communication centre, which includes the issue, topic or conflict at hand, has been "filtered" by the facts, interpretations, thoughts, feelings, intentions, and choices of behaviour / actions.

Listening and Feedback

Did I say what I meant to say? - Invite feedback to clarify communication.

Someone who's not listening lets their mind drift and is already preparing the next argument or opposing thought; inaccurate feedback or limited eye contact.

Listening is an active, not a passive process. When two people argue, they only hear "what they want to hear", not what's actually said. This equates to the accusation of "not listening". Most couples start arguing and within 5 minutes are arguing about the way they are arguing.

Don't argue when you're angry - you will not be able to listen objectively. Give yourself time to cool down and then broach the subject when you are in a more reasonable frame of mind.

It's important to give feedback - checking and confirming. Did I understand you correctly? Is this what you mean? I heard you say this: am I right? Feedback can be verbal / non-verbal e.g. a nod, smile, silence or a cold shoulder. No feedback is in itself a form of feedback.

If the words and actions contradict each other, it is better to believe the actions!

Conflict Resolution

Conflict resolution can either be Constructive or Destructive.

Destructive Style - hinders or inhibits the conflict resolution process:

Confrontational (win or lose, blaming)

Sabotage (focus on weak points, shaming)

Manipulation (blackmail, withdrawal)

Giving in (passive, submissive)

Avoidance (denial, withdrawal)

Constructive Style � trying to minimize the issues and avoiding the difficulties in resolving the problems:

Compromise (meet halfway, understanding)

Accommodate (open discussion, communication without confrontation)

Partnership (solutions, forgiveness, honesty)

When trying to resolve conflicts, try to clarify your goals, as you will probably share many of the same goals despite of your differences. Avoid bargaining, as this may lead to each party taking a rigid position which in turn can flare tempers.

When resolving conflicts, remember that their causes may run deep. Sweeping issues under the carpet isn�t going to work in the long term, as old baggage will be brought up each time an argument starts. Try to fully resolve each issue as it comes along. You may find the following method useful:

1. Ask the other person for their feelings. Your conflict probably isn�t about the issue that caused it to start in the first place. Don�t forget that your goal is sorting out the problem, not winning an argument!

2. Ask the other person to define the problem. Stick to solving one problem at a time, that way you can understand each problem as the other person sees it.

3. Express your own feelings. Be careful to word them carefully, for example use phrases such as �I feel�� rather than �I think you��

4. Define the problem as you see it. As your feelings come out, the solution may become clearer. Remember that by you listening to the other person; you will have set the tone for them to listen to you.

5. Create multiple solutions. Don�t go back to your original agenda. Aim to find alternative or creative solutions that reduce emotions and tension.

6. Rate the possible solutions. Remember that no one can force an unacceptable solution on the other.

7. Combine and create a mutually acceptable solution. Create something acceptable to both parties, if this doesn�t work � go back to step 1 and ensure both parties are being totally honest.

8. Be sure both parties agree to work towards resolving the issue.

Troubleshooting For Problems in Communication

Control or Power Issues: Effective communication cannot take place if one person has "control" over the other or where there is not mutual respect and equality of relationship. To stay in control leads to relational isolation as the underdog reacts in anger at being manipulated or belittled.

Triangulation: Do not bring in a third party to avoid direct confrontation. If you have a problem with someone, go directly to that person. Don't dump your accusations on mutual friends or your children in the hope of winning support to balance the scales in your favour - it leads to more substantial and long-lasting damage, especially when a child is used as a weapon between parents.

19 Steps to Effective Communication

1. See communication as an opportunity to praise, build-up, affirm, heal, support and give positive reinforcement, rather than to correct, criticise, tear down, hurt, wound, lash out at. Praise opens doors to further communication, while criticism shuts them down.

2. Remember that actions speak louder than words; non-verbal communication usually is more powerful than verbal communication. Avoid double messages in which the verbal and the non-verbal messages convey something contradictory. (Credibility gap)

3. Define what is important and stress it; define what is unimportant and de-emphasise or ignore it. Avoid fault-finding.

4. Communicate in ways that show respect for the other person�s worth as a human being. �Avoid statements which begin with the words �You never �� or �I think you ��.

5. Be clear and specific in your communication. Avoid vagueness.

6. Be realistic and reasonable in your statements. Avoid exaggeration and sentences which begin with �You always ��

7. Test all your assumptions verbally by asking if they are accurate. Avoid acting until this is done.

8. Recognize that each event can be seen from different points of view. Avoid assuming that other people see things like you do. (Perception)

9. Recognize that your family members and close friends are experts on you and your behaviour. Avoid the tendency to deny their observations about you � especially if you are not sure.

10. Recognize that disagreement can be a meaningful form of communication. Avoid destructive arguments.

11. Be honest and open about your feelings and viewpoints. Bring up all significant problems even if you are afraid that doing so will disturb another person. Speak the truth in love. Avoid sullen silences.

12. Do not put down and/or manipulate the other person with tactics such as ridicule, interrupting, name-calling, changing the subject, blaming, bugging, sarcasm, criticism, pouting, guilt-inducing, etc. Avoid the one-upmanship game.

13. Be more concerned about how your communication affects others than about what you intended. Avoid getting bitter if you are misunderstood.

14. Accept all feelings and try to understand why others feel and act as they do. Avoid the tendency to say, �you shouldn�t feel like that.�

15. Be tactful considerate and courteous. Avoid taking advantage of the other person�s feelings.

16. Ask questions and listen carefully. Avoid preaching or lecturing.

17. Do not use excuses. Avoid falling for the excuses of others.

18. Speak kindly politely and softly. Avoid nagging yelling or whining.

19. Recognize the value of humour and seriousness. Avoid destructive teasing.

Summary

As you look ahead to new relationships, you need to be able to break old and faulty communication patterns to allow for healthier interaction. The use of praise and positive reinforcement will reconstruct wounded and broken self-images and will build self-esteem, particularly in children. By becoming an effective communicator, you will also grow and become a better person which will positively enhance all your relationships.